Population-based Genetic Testing for Precision Prevention
نویسندگان
چکیده
منابع مشابه
Robust tests for testing the parameters of a normal population
This article aims to provide a simple robust method to test the parameters of a normal population by using the new diagnostic tool called the “Forward Search” (FS) method. The most commonly used procedures to test the mean and variance of a normal distribution are Student’s t test and Chi-square test, respectively. These tests suffer from the presence of outliers. We introduce the FS version of...
متن کاملGenetic hypercoagulability: prevention suggests testing family members.
Dahlback in 1993 and Bertina in 1994 made the landmark discovery that resistance to activated protein C due to a point mutation in the factor V gene (G1691A in exon 10, leading to Arg506Gln) is associated with a 6to 8-fold increased risk of venous thrombosis.1,2 The importance of these findings, which have since been confirmed and cited more than 2000 times in the medical literature, is due to ...
متن کاملPredictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population
PURPOSE The National Comprehensive Cancer Network (NCCN) has proposed guidelines for the genetic testing of the BRCA1 and BRCA2 genes, based on studies in western populations. This current study assessed potential predictive factors for BRCA mutation probability, in an Asian population. METHODS A total of 359 breast cancer patients, who presented with either a family history (FH) of breast an...
متن کاملPrecision prevention of cancer.
Most tumors are incurable once they reach an advanced (e.g., metastatic) stage. Even for those cancers with effective treatment options, prevention has the greatest potential to reduce the burden of cancer in the general population. The 2014 AACR Cancer Progress Report states that a large proportion of cancers could be prevented by modifying factors such as tobacco use (33%), obesity (20%), and...
متن کاملGenetic Algorithm Based Software Testing
In this work we are studying possibilities to test software using genetic algorithm search. The idea is to produce test cases in order to nd problematic situations like processing time extremes. The proposed test method comes under the heading of automated dynamic stress testing.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2020
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-20-0002